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Up-regulation of c-jun mRNA in cardiac myocytes requires the extracellular signal-regulated kinase cascade, but c-Jun N-terminal kinases are required for efficient up-regulation of c-Jun protein.
Cardiac hypertrophy, an important adaptational response, is associated with up-regulation of the immediate early gene, c- jun, which encodes the c-Jun transcription factor. c-Jun may feed back to up-regulate its own transcription and, since the c-Jun N-terminal kinase (JNK) family of mitogen-activat...
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Autors principals: | , , , , , |
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Format: | Artigo |
Idioma: | Inglês |
Publicat: |
2002
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Matèries: | |
Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1222976/ https://ncbi.nlm.nih.gov/pubmed/12169099 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20021083 |
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