Up-regulation of c-jun mRNA in cardiac myocytes requires the extracellular signal-regulated kinase cascade, but c-Jun N-terminal kinases are required for efficient up-regulation of c-Jun protein.

Cardiac hypertrophy, an important adaptational response, is associated with up-regulation of the immediate early gene, c- jun, which encodes the c-Jun transcription factor. c-Jun may feed back to up-regulate its own transcription and, since the c-Jun N-terminal kinase (JNK) family of mitogen-activat...

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Detalhes bibliográficos
Main Authors: Clerk, Angela, Kemp, Timothy J, Harrison, Joanne G, Mullen, Anthony J, Barton, Paul J R, Sugden, Peter H
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222976/
https://ncbi.nlm.nih.gov/pubmed/12169099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20021083
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