Down syndrome—recent progress and future prospects

Por Wiseman, Frances K., Alford, Kate A., Tybulewicz, Victor L.J., Fisher, Elizabeth M.C.
Publicado em 2009

Down syndrome and the molecular pathogenesis resulting from trisomy of human chromosome 21

Por Ruparelia, Aarti, Wiseman, Frances, Sheppard, Olivia, Tybulewicz, Victor L.J., Fisher, Elizabeth M.C.
Publicado em 2010

Mouse Models of Aneuploidy

Por Sheppard, Olivia, Wiseman, Frances K., Ruparelia, Aarti, Tybulewicz, Victor L. J., Fisher, Elizabeth M. C.
Publicado em 2012

Generation of a panel of antibodies against proteins encoded on human chromosome 21

Por Wiseman, Frances K, Sheppard, Olivia, Linehan, Jacqueline M, Brandner, Sebastian, Tybulewicz, Victor LJ, Fisher, Elizabeth MC
Publicado em 2010

Tc1 mouse model of trisomy-21 dissociates properties of short- and long-term recognition memory

Por Hall, Jessica H., Wiseman, Frances K., Fisher, Elizabeth M.C., Tybulewicz, Victor L.J., Harwood, John L., Good, Mark A.
Publicado no Neurobiol Learn Mem (2016)

Protein profiles in Tc1 mice implicate novel pathway perturbations in the Down syndrome brain

Por Ahmed, Md. Mahiuddin, Dhanasekaran, A. Ranjitha, Tong, Suhong, Wiseman, Frances K., Fisher, Elizabeth M.C., Tybulewicz, Victor L.J., Gardiner, Katheleen J.
Publicado em 2013

The Glycosylation Status of PrP(C) Is a Key Factor in Determining Transmissible Spongiform Encephalopathy Transmission between Species

Por Wiseman, Frances K., Cancellotti, Enrico, Piccardo, Pedro, Iremonger, Kayleigh, Boyle, Aileen, Brown, Deborah, Ironside, James W., Manson, Jean C., Diack, Abigail B.
Publicado no J Virol (2015)

A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome

Por Wiseman, Frances K., Al-Janabi, Tamara, Hardy, John, Karmiloff-Smith, Annette, Nizetic, Dean, Tybulewicz, Victor L. J., Fisher, Elizabeth M. C., Strydom, André
Publicado no Nat Rev Neurosci (2015)

Altered regulation of tau phosphorylation in a mouse model of down syndrome aging

Por Sheppard, Olivia, Plattner, Florian, Rubin, Anna, Slender, Amy, Linehan, Jacqueline M., Brandner, Sebastian, Tybulewicz, Victor L.J., Fisher, Elizabeth M.C., Wiseman, Frances K.
Publicado em 2012

Replication-timing boundaries facilitate cell-type and species-specific regulation of a rearranged human chromosome in mouse

Por Pope, Benjamin D., Chandra, Tamir, Buckley, Quinton, Hoare, Matthew, Ryba, Tyrone, Wiseman, Frances K., Kuta, Anna, Wilson, Michael D., Odom, Duncan T., Gilbert, David M.
Publicado em 2012

Automatic Structural Parcellation of Mouse Brain MRI Using Multi-Atlas Label Fusion

Por Ma, Da, Cardoso, Manuel J., Modat, Marc, Powell, Nick, Wells, Jack, Holmes, Holly, Wiseman, Frances, Tybulewicz, Victor, Fisher, Elizabeth, Lythgoe, Mark F., Ourselin, Sébastien
Publicado em 2014

The integration site of the APP transgene in the J20 mouse model of Alzheimer’s disease

Por Tosh, Justin L., Rickman, Matthew, Rhymes, Ellie, Norona, Frances E., Clayton, Emma, Mucke, Lennart, Isaacs, Adrian M., Fisher, Elizabeth M.C., Wiseman, Frances K.
Publicado no Wellcome Open Res (2018)

Structural correlates of active-staining following magnetic resonance microscopy in the mouse brain

Por Cleary, Jon O., Wiseman, Frances K., Norris, Francesca C., Price, Anthony N., Choy, ManKin, Tybulewicz, Victor L.J., Ordidge, Roger J., Brandner, Sebastian, Fisher, Elizabeth M.C., Lythgoe, Mark F.
Publicado em 2011

Changing Paradigms in Down Syndrome: The First International Conference of the Trisomy 21 Research Society

Por Delabar, Jean-Maurice, Allinquant, Bernadette, Bianchi, Diana, Blumenthal, Tom, Dekker, Alain, Edgin, Jamie, O'Bryan, John, Dierssen, Mara, Potier, Marie-Claude, Wiseman, Frances, Guedj, Faycal, Créau, Nicole, Reeves, Roger, Gardiner, Katheleen, Busciglio, Jorge
Publicado no Mol Syndromol (2016)

Overexpression of the Hspa13 (Stch) gene reduces prion disease incubation time in mice

Por Grizenkova, Julia, Akhtar, Shaheen, Hummerich, Holger, Tomlinson, Andrew, Asante, Emmanuel A., Wenborn, Adam, Fizet, Jérémie, Poulter, Mark, Wiseman, Frances K., Fisher, Elizabeth M. C., Tybulewicz, Victor L. J., Brandner, Sebastian, Collinge, John, Lloyd, Sarah E.
Publicado em 2012

Fully-Automated μMRI Morphometric Phenotyping of the Tc1 Mouse Model of Down Syndrome

Por Powell, Nick M., Modat, Marc, Cardoso, M. Jorge, Ma, Da, Holmes, Holly E., Yu, Yichao, O’Callaghan, James, Cleary, Jon O., Sinclair, Ben, Wiseman, Frances K., Tybulewicz, Victor L. J., Fisher, Elizabeth M. C., Lythgoe, Mark F., Ourselin, Sébastien
Publicado no PLoS One (2016)

Massively Parallel Sequencing Reveals the Complex Structure of an Irradiated Human Chromosome on a Mouse Background in the Tc1 Model of Down Syndrome

Por Gribble, Susan M., Wiseman, Frances K., Clayton, Stephen, Prigmore, Elena, Langley, Elizabeth, Yang, Fengtang, Maguire, Sean, Fu, Beiyuan, Rajan, Diana, Sheppard, Olivia, Scott, Carol, Hauser, Heidi, Stephens, Philip J., Stebbings, Lucy A., Ng, Bee Ling, Fitzgerald, Tomas, Quail, Michael A., Banerjee, Ruby, Rothkamm, Kai, Tybulewicz, Victor L. J., Fisher, Elizabeth M. C., Carter, Nigel P.
Publicado em 2013