Fully-Automated μMRI Morphometric Phenotyping of the Tc1 Mouse Model of Down Syndrome

We describe a fully automated pipeline for the morphometric phenotyping of mouse brains from μMRI data, and show its application to the Tc1 mouse model of Down syndrome, to identify new morphological phenotypes in the brain of this first transchromosomic animal carrying human chromosome 21. We incor...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Powell, Nick M., Modat, Marc, Cardoso, M. Jorge, Ma, Da, Holmes, Holly E., Yu, Yichao, O’Callaghan, James, Cleary, Jon O., Sinclair, Ben, Wiseman, Frances K., Tybulewicz, Victor L. J., Fisher, Elizabeth M. C., Lythgoe, Mark F., Ourselin, Sébastien
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033246/
https://ncbi.nlm.nih.gov/pubmed/27658297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0162974
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