Fully-Automated μMRI Morphometric Phenotyping of the Tc1 Mouse Model of Down Syndrome

We describe a fully automated pipeline for the morphometric phenotyping of mouse brains from μMRI data, and show its application to the Tc1 mouse model of Down syndrome, to identify new morphological phenotypes in the brain of this first transchromosomic animal carrying human chromosome 21. We incor...

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Vydáno v:PLoS One
Hlavní autoři: Powell, Nick M., Modat, Marc, Cardoso, M. Jorge, Ma, Da, Holmes, Holly E., Yu, Yichao, O’Callaghan, James, Cleary, Jon O., Sinclair, Ben, Wiseman, Frances K., Tybulewicz, Victor L. J., Fisher, Elizabeth M. C., Lythgoe, Mark F., Ourselin, Sébastien
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033246/
https://ncbi.nlm.nih.gov/pubmed/27658297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0162974
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