Altered regulation of tau phosphorylation in a mouse model of down syndrome aging

Down syndrome (DS) results from trisomy of human chromosome 21 (Hsa21) and is associated with an increased risk of Alzheimer's disease (AD). Here, using the unique transchromosomic Tc1 mouse model of DS we investigate the influence of trisomy of Hsa21 on the protein tau, which is hyperphosphory...

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Detalhes bibliográficos
Main Authors: Sheppard, Olivia, Plattner, Florian, Rubin, Anna, Slender, Amy, Linehan, Jacqueline M., Brandner, Sebastian, Tybulewicz, Victor L.J., Fisher, Elizabeth M.C., Wiseman, Frances K.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2012
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Abstract of Online Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314962/
https://ncbi.nlm.nih.gov/pubmed/21843906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2011.06.025
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