In vivo and ex vivo analyses of amyloid toxicity in the Tc1 mouse model of Down syndrome

RATIONALE: The prevalence of Alzheimer’s disease is increased in people with Down syndrome. The pathology appears much earlier than in the general population, suggesting a predisposition to develop Alzheimer’s disease. Down syndrome results from trisomy of human chromosome 21, leading to overexpress...

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Veröffentlicht in:J Psychopharmacol
Hauptverfasser: Naert, Gaëlle, Ferré, Valentine, Keller, Emeline, Slender, Amy, Gibbins, Dorota, Fisher, Elizabeth MC, Tybulewicz, Victor LJ, Maurice, Tangui
Format: Artigo
Sprache:Inglês
Veröffentlicht: SAGE Publications 2017
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Original Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5815426/
https://ncbi.nlm.nih.gov/pubmed/29215943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0269881117743484
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