Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel

Down syndrome (DS), caused by trisomy of human chromosome 21 (Hsa21), is the most common cause of congenital heart defects (CHD), yet the genetic and mechanistic causes of these defects remain unknown. To identify dosage-sensitive genes that cause DS phenotypes, including CHD, we used chromosome eng...

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Bibliografiska uppgifter
I publikationen:eLife
Huvudupphovsmän: Lana-Elola, Eva, Watson-Scales, Sheona, Slender, Amy, Gibbins, Dorota, Martineau, Alexandrine, Douglas, Charlotte, Mohun, Timothy, Fisher, Elizabeth MC, Tybulewicz, Victor LJ
Materialtyp: Artigo
Språk:Inglês
Publicerad: eLife Sciences Publications, Ltd 2016
Ämnen:
Developmental Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764572/
https://ncbi.nlm.nih.gov/pubmed/26765563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.11614
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