Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel

Down syndrome (DS), caused by trisomy of human chromosome 21 (Hsa21), is the most common cause of congenital heart defects (CHD), yet the genetic and mechanistic causes of these defects remain unknown. To identify dosage-sensitive genes that cause DS phenotypes, including CHD, we used chromosome eng...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Lana-Elola, Eva, Watson-Scales, Sheona, Slender, Amy, Gibbins, Dorota, Martineau, Alexandrine, Douglas, Charlotte, Mohun, Timothy, Fisher, Elizabeth MC, Tybulewicz, Victor LJ
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764572/
https://ncbi.nlm.nih.gov/pubmed/26765563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.11614
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