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Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel

Down syndrome (DS), caused by trisomy of human chromosome 21 (Hsa21), is the most common cause of congenital heart defects (CHD), yet the genetic and mechanistic causes of these defects remain unknown. To identify dosage-sensitive genes that cause DS phenotypes, including CHD, we used chromosome eng...

詳細記述

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書誌詳細
出版年:eLife
主要な著者: Lana-Elola, Eva, Watson-Scales, Sheona, Slender, Amy, Gibbins, Dorota, Martineau, Alexandrine, Douglas, Charlotte, Mohun, Timothy, Fisher, Elizabeth MC, Tybulewicz, Victor LJ
フォーマット: Artigo
言語:Inglês
出版事項: eLife Sciences Publications, Ltd 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4764572/
https://ncbi.nlm.nih.gov/pubmed/26765563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.11614
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