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A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome
Down syndrome, which arises in individuals carrying an extra copy of chromosome 21, is associated with a greatly increased risk of early-onset Alzheimer disease. It is thought that this risk is conferred by the presence of three copies of the gene encoding amyloid precursor protein (APP) — an Alzhei...
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| Publicado no: | Nat Rev Neurosci |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4678594/ https://ncbi.nlm.nih.gov/pubmed/26243569 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrn3983 |
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