OX40 agonist immunotherapy expands tumor reactive CD8 T cells with a unique T cell receptor repertoire and synergizes with PDL-1 blockade to promote tumor regression

Por Moran, Amy, Polesso, Fanny, Weinberg, Andrew
Publicado no J Immunother Cancer (2014)

Targeting macrophages in the tumour environment to enhance the efficacy of αOX40 therapy

Por Gough, Michael J, Killeen, N, Weinberg, Andrew D
Publicado em 2012

Immunotherapy expands and maintains the function of high affinity tumor infiltrating CD8 T cells in situ

Por Moran, Amy E., Polesso, Fanny, Weinberg, Andrew D.
Publicado no J Immunol (2016)

The role of OX40-mediated co-stimulation in T cell activation and survival

Por Redmond, William L., Ruby, Carl E., Weinberg, Andrew D.
Publicado em 2009

Ligation of the OX40 co-stimulatory receptor reverses self-Ag and tumor-induced CD8 T cell anergy in vivo

Por Redmond, William L., Gough, Michael J., Weinberg, Andrew D.
Publicado em 2009

The TNFRs OX40, 4-1BB, and CD40 as targets for cancer immunotherapy

Por Moran, Amy E., Kovacsovics-Bankowski, Magdalena, Weinberg, Andrew D.
Publicado em 2013

Dual Anti-OX40/IL-2 Therapy Augments Tumor Immunotherapy via IL-2R-Mediated Regulation of OX40 Expression

Por Redmond, William L., Triplett, Todd, Floyd, Kevin, Weinberg, Andrew D.
Publicado em 2012

OX40L Regulates Inflammation and Mortality in the Innate Immune Response to Sepsis

Por Karulf, Matthew, Kelly, Ann, Weinberg, Andrew D., Gold, Jeffrey A.
Publicado em 2010

OX40 engagement stabilizes Mxd4 and Mnt protein levels in antigen-stimulated T cells leading to an increase in survival

Por Vasilevsky, Nicole A., Ruby, Carl E., Hurlin, Peter J., Weinberg, Andrew D.
Publicado em 2011

Finding the right balance: aOX40 immunotherapy enhances effector T cell function without impairing regulatory T cells intrinsic suppressive capacity in mouse tumor models

Por Moran, Amy, Polesso, Fanny, Sarker, Minhazur, Parker, David, Murray, Susan E, Weinberg, Andrew
Publicado no J Immunother Cancer (2015)

4-1BB and OX40 stimulation enhance CD8 and CD4 T-cell responses to a DNA prime, poxvirus boost vaccine

Por Munks, Michael W, Mourich, Dan V, Mittler, Robert S, Weinberg, Andrew D, Hill, Ann B
Publicado em 2004

STAT3 signaling is required for anti-OX40/TGF-β receptor blockade-mediated regression of large established tumors

Por Akporiaye, Emmanuel T, Tucker, Christopher, Triplett, Todd, Garrison, Kendra, Sun, Lihong, Ling, Leona, Weinberg, Andrew
Publicado em 2013

Activation of OX40 Prolongs and Exacerbates Autoimmune Experimental Uveitis

Por Wu, Xiumei, Rosenbaum, James T., Adamus, Grazyna, Zhang, Gary L., Duan, Jie, Weinberg, Andrew, Zhang, Zili
Publicado em 2011

The small molecule TGF-β signaling inhibitor SM16 synergizes with agonistic OX40 antibody to suppress established mammary tumors and reduce spontaneous metastasis

Por Garrison, Kendra, Hahn, Tobias, Lee, Wen-Cherng, Ling, Leona E., Weinberg, Andrew D., Akporiaye, Emmanuel T.
Publicado em 2011

Science gone translational: the OX40 agonist story

Por Weinberg, Andrew D., Morris, Nicholas P., Kovacsovics-Bankowski, Magdalena, Urba, Walter J., Curti, Brendan D.
Publicado em 2011

Phase I/II clinical trial of anti-OX40, radiation and cyclophosphamide in patients with prostate cancer: immunological analysis

Por Kovacsovics-Bankowski, Magdalena, Chisholm, Lana, Vercellini, Jonna, Crittenden, Marka, Lary, Scot, Curti, Brendan, Weinberg, Andrew
Publicado em 2013

Caloric restriction maintains OX40 agonist-mediated tumor immunity and CD4 T cell priming during aging

Por Farazi, Michelle, Nguyen, Justine, Goldufsky, Josef, Linnane, Stephanie, Lukaesko, Lisa, Weinberg, Andrew D., Ruby, Carl E.
Publicado em 2014

Activation of OX40 Augments Th17 Cytokine Expression and Antigen-Specific Uveitis

Por Zhang, Zili, Zhong, Wenwei, Hinrichs, David, Wu, Xiumei, Weinberg, Andrew, Hall, Mark, Spencer, Doran, Wegmann, Keith, Rosenbaum, James T.
Publicado em 2010

Development and Characterization of Recombinant Human Fc:OX40L fusion protein linked via a coiled-coil trimerization domain

Por Morris, Nicholas P., Peters, Carmen, Montler, Ryan, Hu, Hong-Ming, Curti, Brendan D., Urba, Walter J., Weinberg, Andrew D.
Publicado em 2007

OX40 and other immunoregulatory molecules are highly expressed on tumor infiltrating lymphocytes in oral, head and neck squamous cell carcinoma

Por Montler, Ryan, Bell, Richard B, Leidner, Rom, Crittenden, Marka, Bui, Tuan, Cheng, Allen, Patel, Ashish, Tucker, Christopher, Thalhofer, Colin, Weinberg, Andrew
Publicado no J Immunother Cancer (2014)