The small molecule TGF-β signaling inhibitor SM16 synergizes with agonistic OX40 antibody to suppress established mammary tumors and reduce spontaneous metastasis

Effective tumor immunotherapy may require not only activation of anti-tumor effector cells, but also abrogation of tumor-mediated immunosuppression. The cytokine TGF-β, is frequently elevated in the tumor microenvironment and is a potent immunosuppressive agent and promoter of tumor metastasis. OX40...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Garrison, Kendra, Hahn, Tobias, Lee, Wen-Cherng, Ling, Leona E., Weinberg, Andrew D., Akporiaye, Emmanuel T.
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer-Verlag 2011
Materias:
Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3595193/
https://ncbi.nlm.nih.gov/pubmed/21971588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-011-1119-y
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares