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OX40 Agonists can drive Treg expansion if the cytokine milieu is right
We report that OX40 stimulation drives all lineages of CD4 T cell development including Treg and the plasticity of the response is dependant on local cytokines. In TGF-β1-treated cultures, OX40 agonist increased IFN-γ and IL-4 production and diverted T cells from the Treg lineage. However, cytokine...
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| Izdano u: | J Immunol |
|---|---|
| Glavni autori: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2009
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4625917/ https://ncbi.nlm.nih.gov/pubmed/19786544 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0901112 |
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