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OX40 Agonists can drive Treg expansion if the cytokine milieu is right

We report that OX40 stimulation drives all lineages of CD4 T cell development including Treg and the plasticity of the response is dependant on local cytokines. In TGF-β1-treated cultures, OX40 agonist increased IFN-γ and IL-4 production and diverted T cells from the Treg lineage. However, cytokine...

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Bibliografische gegevens
Gepubliceerd in:J Immunol
Hoofdauteurs: Ruby, Carl E, Yates, Melissa A, Hirschhorn-Cymerman, Daniel, Chlebeck, Peter, Wolchok, Jedd D, Houghton, Alan N, Offner, Halina, Weinberg, Andrew D
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2009
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4625917/
https://ncbi.nlm.nih.gov/pubmed/19786544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0901112
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