Curcumin inhibits the activity of ABCG2/BCRP1, a multidrug resistance-linked ABC drug transporter in mice

by Shukla, Suneet, Zaher, Hani, Hartz, Anika, Bauer, Björn, Ware, Joseph A., Ambudkar, Suresh V.
Published 2008

Intrinsic and Extrinsic Pharmacokinetic Variability of Small Molecule Targeted Cancer Therapy

by Reyner, Eric, Lum, Bert, Jing, Jing, Kagedal, Matts, Ware, Joseph A., Dickmann, Leslie J.
Published in Clin Transl Sci (2019)

Mechanistic physiology-based pharmacokinetic modeling to elucidate vincristine-induced peripheral neuropathy following treatment with novel kinase inhibitors

by Pilla Reddy , Venkatesh, Fretland, Adrian J., Zhou, Diansong, Sharma, Shringi, Chen, Buyun, Vishwanathan, Karthick, McGinnity, Dermot F., Xu, Yan, Ware, Joseph A.
Published in Cancer Chemother Pharmacol (2021)

Gastric Re-acidification with Betaine HCl in Healthy Volunteers with Rabeprazole-Induced Hypochlorhydria

by Yago, Marc Anthony R., Frymoyer, Adam R., Smelick, Gillian S., Frassetto, Lynda A., Budha, Nageshwar R., Dresser, Mark J., Ware, Joseph A., Benet, Leslie Z.
Published 2013

Combining “Bottom‐up” and “Top‐down” Approaches to Assess the Impact of Food and Gastric pH on Pictilisib (GDC‐0941) Pharmacokinetics

by Lu, Tong, Fraczkiewicz, Grazyna, Salphati, Laurent, Budha, Nageshwar, Dalziel, Gena, Smelick, Gillian S., Morrissey, Kari M., Davis, John D., Jin, Jin Y., Ware, Joseph A.
Published in CPT Pharmacometrics Syst Pharmacol (2017)

Targeted Disruption of Murine Organic Anion-Transporting Polypeptide 1b2 (oatp1b2/Slco1b2) Significantly Alters Disposition of Prototypical Drug Substrates Pravastatin and Rifampin

by Zaher, Hani, Schwabedissen, Henriette E. Meyer zu, Tirona, Rommel G., Cox, Melissa L., Obert, Leslie A., Agrawal, Nidhi, Palandra, Joe, Stock, Jeffrey L., Kim, Richard B., Ware, Joseph A.
Published 2008

The Use of Betaine HCl to Enhance Dasatinib Absorption in Healthy Volunteers with Rabeprazole-Induced Hypochlorhydria

by Yago, Marc R., Frymoyer, Adam, Benet, Leslie Z., Smelick, Gillian S., Frassetto, Lynda A., Ding, Xiao, Dean, Brian, Salphati, Laurent, Budha, Nageshwar, Jin, Jin Y., Dresser, Mark J., Ware, Joseph A.
Published in AAPS J (2014)

Disease-Associated Changes in Drug Transporters May Impact the Pharmacokinetics and/or Toxicity of Drugs: A White Paper from the International Transporter Consortium

by Evers, Raymond, Piquette-Miller, Micheline, Polli, Joseph W., Russel, Frans G. M., Sprowl, Jason A., Tohyama, Kimio, Ware, Joseph A., de Wildt, Saskia N., Xie, Wen, Brouwer, Kim L. R.
Published in Clin Pharmacol Ther (2018)

Breast cancer resistance protein (ABCG2) and drug disposition: intestinal expression, polymorphisms and sulfasalazine as an in vivo probe

by Urquhart, Bradley L., Ware, Joseph A., Tirona, Rommel G., Ho, Richard H., Leake, Brenda F., Schwarz, Ute I., Zaher, Hani, Palandra, Joe, Gregor, Jamie C., Dresser, George K., Kim, Richard B.
Published 2008

Investigation of the absolute bioavailability and human mass balance of navoximod, a novel IDO1 inhibitor

by Ma, Shuguang, Suchomel, Julia, Yanez, Evelyn, Yost, Edward, Liang, Xiaorong, Zhu, Rui, Le, Hoa, Siebers, Nicholas, Joas, Lori, Morley, Roland, Royer‐Joo, Stephanie, Pirzkall, Andrea, Salphati, Laurent, Ware, Joseph A., Morrissey, Kari M.
Published in Br J Clin Pharmacol (2019)

A Phase I Dose‐Escalation Study of the Safety and Pharmacokinetics of Pictilisib in Combination with Erlotinib in Patients with Advanced Solid Tumors

by Leong, Stephen, Moss, Rebecca A., Bowles, Daniel W., Ware, Joseph A., Zhou, Jing, Spoerke, Jill M., Lackner, Mark R., Shankar, Geetha, Schutzman, Jennifer L., van der Noll, Ruud, Voest, Emile E., Schellens, Jan H.M.
Published in Oncologist (2017)

Hepatic OATP Transporter and Thyroid Hormone Receptor Interplay Determines Cholesterol and Glucose Homeostasis

by Meyer zu Schwabedissen, Henriette E., Ware, Joseph A., Finkelstein, David, Chaudhry, Amarjit S., Lemay, Sara, Leon-Ponte, Matilde, Strom, Stephen C., Zaher, Hani, Schwarz, Ute I., Freeman, David J., Schuetz, Erin G., Tirona, Rommel G., Kim, Richard B.
Published 2011

Phase I Dose Escalation Study of Taselisib (GDC-0032), an Oral PI3K Inhibitor, in Patients with Advanced Solid Tumors

by Juric, Dejan, Krop, Ian, Ramanathan, Ramesh K., Wilson, Timothy R., Ware, Joseph A., Sanabria Bohorquez, Sandra M., Savage, Heidi M., Sampath, Deepak, Salphati, Laurent, Lin, Ray S., Jin, Huan, Parmar, Hema, Hsu, Jerry Y., Von Hoff, Daniel D., Baselga, Jose
Published in Cancer Discov (2017)

A Multicenter, Single-Arm, Open-Label, Phase 2 Study of Apitolisib (GDC-0980) for the Treatment of Recurrent or Persistent Endometrial Carcinoma (MAGGIE study)

by Makker, Vicky, Recio, Fernando O., Ma, Ling, Matulonis, Ursula, Lauchle, Jennifer O., Parmar, Hema, Gilbert, Houston N., Ware, Joseph A., Zhu, Rui, Lu, Shan, Huw, Ling-Yuh, Wang, Yulei, Koeppen, Hartmut, Spoerke, Jill M., Lackner, Mark R., Aghajanian, Carol
Published in Cancer (2016)

Phase I Study of Apitolisib (GDC-0980), Dual Phosphatidylinositol-3-Kinase and Mammalian Target of Rapamycin Kinase Inhibitor, in Patients with Advanced Solid Tumors

by Dolly, Saoirse O., Wagner, Andrew J., Bendell, Johanna C., Kindler, Hedy L., Krug, Lee M., Seiwert, Tanguy Y., Zauderer, Marjorie G., Lolkema, Martijn P., Apt, Doris, Yeh, Ru-Fang, Fredrickson, Jill O., Spoerke, Jill M., Koeppen, Hartmut, Ware, Joseph A., Lauchle, Jennifer O., Burris, Howard A., de Bono, Johann S.
Published in Clin Cancer Res (2016)

First-in-human Phase I study of Pictilisib (GDC-0941), a potent pan-class I phosphatidylinositol-3-kinase (PI3K) inhibitor, in patients with advanced solid tumors

by Sarker, Debashis, Ang, Joo Ern, Baird, Richard, Kristeleit, Rebecca, Shah, Krunal, Moreno, Victor, Clarke, Paul A., Raynaud, Florence I., Levy, Gallia, Ware, Joseph A, Mazina, Kathryn, Lin, Ray, Wu, Jenny, Fredrickson, Jill, Spoerke, Jill M, Lackner, Mark R, Yan, Yibing, Friedman, Lori S., Kaye, Stan B., Derynck, Mika K., Workman, Paul, de Bono, Johann S.
Published in Clin Cancer Res (2014)

Randomized Open-Label Phase II Trial of Apitolisib (GDC-0980), a Novel Inhibitor of the PI3K/Mammalian Target of Rapamycin Pathway, Versus Everolimus in Patients With Metastatic Re...

by Powles, Thomas, Lackner, Mark R., Oudard, Stéphane, Escudier, Bernard, Ralph, Christy, Brown, Janet E., Hawkins, Robert E., Castellano, Daniel, Rini, Brian I., Staehler, Michael D., Ravaud, Alain, Lin, Wei, O’Keeffe, Bridget, Wang, Yulei, Lu, Shan, Spoerke, Jill M., Huw, Ling-Yuh, Byrtek, Michelle, Zhu, Rui, Ware, Joseph A., Motzer, Robert J.
Published in J Clin Oncol (2016)