Targeted Disruption of Murine Organic Anion-Transporting Polypeptide 1b2 (oatp1b2/Slco1b2) Significantly Alters Disposition of Prototypical Drug Substrates Pravastatin and Rifampin

Organic anion transporting polypeptide (OATP) 1B1 and 1B3 are widely acknowledged as important and rate-limiting to the hepatic uptake of many drugs in clinical use. Accordingly, to better understand the in vivo relevance of OATP1B transporters, targeted disruption of murine Slco1b2 gene was carried...

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Main Authors: Zaher, Hani, Schwabedissen, Henriette E. Meyer zu, Tirona, Rommel G., Cox, Melissa L., Obert, Leslie A., Agrawal, Nidhi, Palandra, Joe, Stock, Jeffrey L., Kim, Richard B., Ware, Joseph A.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2562886/
https://ncbi.nlm.nih.gov/pubmed/18413659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.046458
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