Curcumin inhibits the activity of ABCG2/BCRP1, a multidrug resistance-linked ABC drug transporter in mice

PURPOSE: To evaluate the in vivo efficacy of curcumin as an inhibitor of the multidrug-resistance-linked ATP Binding Cassette (ABC) drug transporter, ABCG2. METHODS: Photoaffinity labeling with [(125)I]-iodoarylazidoprazosin was used to characterize the interaction of sulfasalazine, a substrate of t...

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Bibliographic Details
Main Authors: Shukla, Suneet, Zaher, Hani, Hartz, Anika, Bauer, Björn, Ware, Joseph A., Ambudkar, Suresh V.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662629/
https://ncbi.nlm.nih.gov/pubmed/18841445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-008-9735-8
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