Biosynthesis of Enediyne Antitumor Antibiotics

Por Van Lanen, Steven G., Shen, Ben
Publicado em 2008

Enzymatic Strategies and Biocatalysts for Amide Bond Formation: Tricks of the Trade Outside of the Ribosome

Por Goswami, Anwesha, Van Lanen, Steven G.
Publicado no Mol Biosyst (2014)

Biosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolism

Por Van Lanen, Steven G., Lin, Shuangjun, Shen, Ben
Publicado em 2008

Regiospecific Chlorination of (S)-β-Tyrosyl-S-Carrier Protein Catalyzed by SgcC3 in the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027

Por Lin, Shuangjun, Van Lanen, Steven G., Shen, Ben
Publicado em 2007

A free-standing condensation enzyme catalyzing ester bond formation in C-1027 biosynthesis

Por Lin, Shuangjun, Van Lanen, Steven G., Shen, Ben
Publicado em 2009

Biosynthetic Origin and Mechanism of Formation of the Aminoribosyl Moiety of Peptidyl Nucleoside Antibiotics

Por Chi, Xiuling, Pahari, Pallab, Nonaka, Koichi, Van Lanen, Steven G.
Publicado em 2011

Fe(II)-dependent, uridine-5′-monophosphate α-ketoglutarate dioxygenases in the synthesis of 5′-modified nucleosides

Por Yang, Zhaoyong, Unrine, Jason, Nonaka, Koichi, Van Lanen, Steven G.
Publicado em 2012

Microbial genome mining for accelerated natural products discovery: is a renaissance in the making?

Por Bachmann, Brian O, Van Lanen, Steven G, Baltz, Richard H
Publicado em 2013

Characterization of SgcE6, the flavin reductase component supporting FAD-dependent halogenation and hydroxylation in the biosynthesis of the enediyne antitumor antibiotic C-1027

Por Van Lanen, Steven G., Lin, Shuangjun, Horsman, Geoff P., Shen, Ben
Publicado em 2009

Characterization of the Maduropeptin Biosynthetic Gene Cluster from Actinomadura madurae ATCC 39144 Supporting a Unifying Paradigm for Enediyne Biosynthesis

Por Van Lanen, Steven G., Oh, Tae-jin, Liu, Wen, Wendt-Pienkowski, Evelyn, Shen, Ben
Publicado em 2007

Enzymatic Total Synthesis of Defucogilvocarcin M and Its Implications for Gilvocarcin Biosynthesis

Por Pahari, Pallab, Kharel, Madan K., Shepherd, Micah D., van Lanen, Steven G., Rohr, Jürgen
Publicado em 2011

The muraminomicin biosynthetic gene cluster and enzymatic formation of the 2-deoxyaminoribosyl appendage

Por Chi, Xiuling, Baba, Satoshi, Tibrewal, Nidhi, Funabashi, Masanori, Nonaka, Koichi, Van Lanen, Steven G.
Publicado em 2012

Functional and Kinetic Analysis of the Phosphotransferase CapP Conferring Selective Self-resistance to Capuramycin Antibiotics

Por Yang, Zhaoyong, Funabashi, Masanori, Nonaka, Koichi, Hosobuchi, Masahiko, Shibata, Tomoyuki, Pahari, Pallab, Van Lanen, Steven G.
Publicado em 2010

Cooperation of Two Bifunctional Enzymes in the Biosynthesis and Attachment of Deoxysugars of the Antitumor Antibiotic Mithramycin

Por Wang, Guojun, Pahari, Pallab, Kharel, Madan K., Chen, Jing, Zhu, Haining, Van Lanen, Steven G., Rohr, Jürgen
Publicado em 2012

From cyclohydrolase to oxidoreductase: Discovery of nitrile reductase activity in a common fold

Por Van Lanen, Steven G., Reader, John S., Swairjo, Manal A., de Crécy-Lagard, Valérie, Lee, Bobby, Iwata-Reuyl, Dirk
Publicado em 2005

Roles of the Synergistic Reductive O-Methyltransferase GilM and of O-Methyltransferase GilMT in the Gilvocarcin Biosynthetic Pathway

Por Tibrewal, Nidhi, Downey, Theresa E., Van Lanen, Steven G., Sharif, Ehesan Ul, O’Doherty, George A., Rohr, Jürgen
Publicado em 2012

The Role of a Nonribosomal Peptide Synthetase in l-Lysine Lactamization During Capuramycin Biosynthesis

Por Liu, Xiaodong, Jin, Yuanyuan, Cui, Zheng, Nonaka, Koichi, Baba, Satoshi, Funabashi, Masanori, Yang, Zhaoyong, Van Lanen, Steven G.
Publicado no Chembiochem (2016)

Insights into the Target Interaction of Naturally Occurring Muraymycin Nucleoside Antibiotics

Por Koppermann, Stefan, Cui, Zheng, Fischer, Patrick D., Wang, Xiachang, Ludwig, Jannine, Thorson, Jon S., Van Lanen, Steven G., Ducho, Christian
Publicado no ChemMedChem (2018)

A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis

Por Zhang, Jian, Van Lanen, Steven G., Ju, Jianhua, Liu, Wen, Dorrestein, Pieter C., Li, Wenli, Kelleher, Neil L., Shen, Ben
Publicado em 2008

Pyridoxal-5′-phosphate as an oxygenase cofactor: Discovery of a carboxamide-forming, α-amino acid monooxygenase-decarboxylase

Por Huang, Ying, Liu, Xiaodong, Cui, Zheng, Wiegmann, Daniel, Niro, Giuliana, Ducho, Christian, Song, Yuan, Yang, Zhaoyong, Van Lanen, Steven G.
Publicado no Proc Natl Acad Sci U S A (2018)