Characterization of the Maduropeptin Biosynthetic Gene Cluster from Actinomadura madurae ATCC 39144 Supporting a Unifying Paradigm for Enediyne Biosynthesis

The biosynthetic gene cluster for the enediyne antitumor antibiotic maduropeptin (MDP) from Actinomadura madurae ATCC 39144 was cloned and sequenced. Cloning of the mdp gene cluster was confirmed by heterologous complementation of enediyne polyketide synthase (PKS) mutants from the C-1027 producer S...

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Bibliographic Details
Main Authors: Van Lanen, Steven G., Oh, Tae-jin, Liu, Wen, Wendt-Pienkowski, Evelyn, Shen, Ben
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2529154/
https://ncbi.nlm.nih.gov/pubmed/17918933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja073275o
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