In Vivo Manipulation of the Bleomycin Biosynthetic Gene Cluster in Streptomyces verticillus ATCC15003 Revealing New Insights into Its Biosynthetic Pathway

Bleomycin (BLM), an important clinically used antitumor compound, and its analogs are challenging to prepare by chemical synthesis. Genetic engineering of the biosynthetic pathway in the producer strain would provide an efficient and convenient method of generating new derivatives of this complex mo...

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Hlavní autoři: Galm, Ute, Wang, Liyan, Wendt-Pienkowski, Evelyn, Yang, Runying, Liu, Wen, Tao, Meifeng, Coughlin, Jane M., Shen, Ben
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2008
Témata:
Metabolism and Bioenergetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2568937/
https://ncbi.nlm.nih.gov/pubmed/18697737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804971200
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