In Vivo Manipulation of the Bleomycin Biosynthetic Gene Cluster in Streptomyces verticillus ATCC15003 Revealing New Insights into Its Biosynthetic Pathway

Bleomycin (BLM), an important clinically used antitumor compound, and its analogs are challenging to prepare by chemical synthesis. Genetic engineering of the biosynthetic pathway in the producer strain would provide an efficient and convenient method of generating new derivatives of this complex mo...

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Detalhes bibliográficos
Main Authors: Galm, Ute, Wang, Liyan, Wendt-Pienkowski, Evelyn, Yang, Runying, Liu, Wen, Tao, Meifeng, Coughlin, Jane M., Shen, Ben
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Metabolism and Bioenergetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2568937/
https://ncbi.nlm.nih.gov/pubmed/18697737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804971200
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