The Biosynthetic Gene Cluster of Zorbamycin, a Member of the Bleomycin Family of Antitumor Antibiotics, from Streptomyces flavoviridis ATCC 21892

The biosynthetic gene cluster for the glycopeptide-derived antitumor antibiotic zorbamycin (ZBM) was cloned by screening a cosmid library of Streptomyces flavoviridis ATCC 21892. Sequence analysis revealed 40 ORFs belonging to the ZBM biosynthetic gene cluster. However, only 23 and 22 ORFs showed st...

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Bibliographic Details
Main Authors: Galm, Ute, Wendt-Pienkowski, Evelyn, Wang, Liyan, George, Nicholas P., Oh, Tae-Jin, Yi, Fan, Tao, Meifeng, Coughlin, Jane M., Shen, Ben
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3086045/
https://ncbi.nlm.nih.gov/pubmed/19081934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b814075h
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