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BlmB and TlmB Provide Resistance to the Bleomycin Family of Antitumor Antibiotics by N-Acetylating Metal-Free Bleomycin, Tallysomycin, Phleomycin, and Zorbamycin
[Image: see text] The bleomycin (BLM) family of glycopeptide-derived antitumor antibiotics consists of BLMs, tallysomycins (TLMs), phleomycins (PLMs), and zorbamycin (ZBM). The self-resistant elements BlmB and TlmB, discovered from the BLM- and TLM-producing organisms Streptomyces verticillus ATCC15...
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| 出版年: | Biochemistry |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American
Chemical Society
2014
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| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4230324/ https://ncbi.nlm.nih.gov/pubmed/25299801 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi501121e |
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