Comparative Analysis of the Biosynthetic Gene Clusters and Pathways for Three Structurally Related Antitumor Antibiotics Bleomycin, Tallysomycin and Zorbamycin

The biosynthetic gene clusters for the glycopeptide antitumor antibiotics bleomycin (BLM), tallysomycin (TLM), and zorbamycin (ZBM) have been recently cloned and characterized from Streptomyces verticillus ATCC15003, Streptoalloteichus hindustanus E465-94 ATCC31158, and Streptomyces flavoviridis ATC...

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Main Authors: Galm, Ute, Wendt-Pienkowski, Evelyn, Wang, Liyan, Huang, Sheng-Xiong, Unsin, Claudia, Tao, Meifeng, Coughlin, Jane M., Shen, Ben
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064724/
https://ncbi.nlm.nih.gov/pubmed/21210656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np1008152
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