Functional and Kinetic Analysis of the Phosphotransferase CapP Conferring Selective Self-resistance to Capuramycin Antibiotics

Capuramycin-related compounds, including A-500359s and A-503083s, are nucleoside antibiotics that inhibit the enzyme bacterial translocase I involved in peptidoglycan cell wall biosynthesis. Within the biosynthetic gene cluster for the A-500359s exists a gene encoding a putative aminoglycoside 3-pho...

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Bibliografiske detaljer
Main Authors: Yang, Zhaoyong, Funabashi, Masanori, Nonaka, Koichi, Hosobuchi, Masahiko, Shibata, Tomoyuki, Pahari, Pallab, Van Lanen, Steven G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Enzymology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857116/
https://ncbi.nlm.nih.gov/pubmed/20202936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.104141
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