A Biocatalytic Approach to Capuramycin Analogues by Exploiting a Substrate Permissive N-Transacylase CapW

Using the ATP-independent transacylase CapW required for the biosynthesis of capuramycin-type antibiotics, we developed a biocatalytic approach for the synthesis of 43 analogues via a one-step aminolysis reaction from the methyl ester precursor as the acyl donor and various nonnative amines as acyl...

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Detalhes bibliográficos
Publicado no:Org Biomol Chem
Main Authors: Liu, Xiaodong, Jin, Yuanyuan, Cai, Wenlong, Green, Keith D., Goswami, Anwesha, Garneau-Tsodikova, Sylvie, Nonaka, Koichi, Baba, Satoshi, Funabashi, Masanori, Yang, Zhaoyong, Van Lanen, Steven G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4864588/
https://ncbi.nlm.nih.gov/pubmed/27050157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6ob00381h
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