The Biosynthesis of Capuramycin-type Antibiotics: IDENTIFICATION OF THE A-102395 BIOSYNTHETIC GENE CLUSTER, MECHANISM OF SELF-RESISTANCE, AND FORMATION OF URIDINE-5′-CARBOXAMIDE

A-500359s, A-503083s, and A-102395 are capuramycin-type nucleoside antibiotics that were discovered using a screen to identify inhibitors of bacterial translocase I, an essential enzyme in peptidoglycan cell wall biosynthesis. Like the parent capuramycin, A-500359s and A-503083s consist of three str...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Cai, Wenlong, Goswami, Anwesha, Yang, Zhaoyong, Liu, Xiaodong, Green, Keith D., Barnard-Britson, Sandra, Baba, Satoshi, Funabashi, Masanori, Nonaka, Koichi, Sunkara, Manjula, Morris, Andrew J., Spork, Anatol P., Ducho, Christian, Garneau-Tsodikova, Sylvie, Thorson, Jon S., Van Lanen, Steven G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4447950/
https://ncbi.nlm.nih.gov/pubmed/25855790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.646414
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