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Roles of the Synergistic Reductive O-Methyltransferase GilM and of O-Methyltransferase GilMT in the Gilvocarcin Biosynthetic Pathway

Two enzymes of the gilvocarcin biosynthetic pathway, GilMT and GilM, with unclear functions were investigated by in vitro studies using purified, recombinant enzymes along with synthetically prepared intermediates. The studies revealed GilMT as a typical S-adenosylmethionine (SAM) dependent O-methyl...

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Detalhes bibliográficos
Main Authors: Tibrewal, Nidhi, Downey, Theresa E., Van Lanen, Steven G., Sharif, Ehesan Ul, O’Doherty, George A., Rohr, Jürgen
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422024/
https://ncbi.nlm.nih.gov/pubmed/22800463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja305113d
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