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Roles of the Synergistic Reductive O-Methyltransferase GilM and of O-Methyltransferase GilMT in the Gilvocarcin Biosynthetic Pathway

Two enzymes of the gilvocarcin biosynthetic pathway, GilMT and GilM, with unclear functions were investigated by in vitro studies using purified, recombinant enzymes along with synthetically prepared intermediates. The studies revealed GilMT as a typical S-adenosylmethionine (SAM) dependent O-methyl...

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Auteurs principaux: Tibrewal, Nidhi, Downey, Theresa E., Van Lanen, Steven G., Sharif, Ehesan Ul, O’Doherty, George A., Rohr, Jürgen
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422024/
https://ncbi.nlm.nih.gov/pubmed/22800463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja305113d
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