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Inactivation of the Ketoreductase gilU Gene of the Gilvocarcin Biosynthetic Gene Cluster Yields New Analogues with Partly Improved Biological Activity
Four new analogues of the gilvocarcin-type aryl-C-glycoside anti-tumor compounds, namely 4′-hydroxy gilvocarcin V (4′-OH-GV), 4′-hydroxy gilvocarcin M, 4′-hydroxy gilvocarcin E and 12-demethyl-defucogilvocarcin V, were produced through inactivation of the gilU gene. The 4′-OH-analogues showed improv...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2680003/ https://ncbi.nlm.nih.gov/pubmed/19067453 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.200800348 |
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