Inactivation of the Ketoreductase gilU Gene of the Gilvocarcin Biosynthetic Gene Cluster Yields New Analogues with Partly Improved Biological Activity

Four new analogues of the gilvocarcin-type aryl-C-glycoside anti-tumor compounds, namely 4′-hydroxy gilvocarcin V (4′-OH-GV), 4′-hydroxy gilvocarcin M, 4′-hydroxy gilvocarcin E and 12-demethyl-defucogilvocarcin V, were produced through inactivation of the gilU gene. The 4′-OH-analogues showed improv...

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Main Authors: Liu, Tao, Kharel, Madan K., Zhu, Lili, Bright, Samuel A., Mattingly, Cynthia, Adams, Val R., Rohr, Jürgen
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680003/
https://ncbi.nlm.nih.gov/pubmed/19067453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.200800348
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