CD133, Selectively Targeting the Root of Cancer

Por Schmohl, Jörg U., Vallera, Daniel A.
Publicado no Toxins (Basel) (2016)

Immunotoxins Targeting B cell Malignancy—Progress and Problems With Immunogenicity

Por Vallera, Daniel A., Kreitman, Robert J.
Publicado no Biomedicines (2018)

A bispecific EpCAM/CD133 targeted toxin is effective against carcinoma

Por Waldron, Nate N., Barsky, Sanford H., Vallera, Daniel A.
Publicado em 2013

Mutagenic Deimmunization of Diphtheria Toxin for Use in Biologic Drug Development

Por Schmohl, Joerg U., Todhunter, Deborah, Oh, Seung, Vallera, Daniel A.
Publicado no Toxins (Basel) (2015)

Natural Killer Cells Unleashed: Checkpoint receptor blockade and BiKE/TriKE utilization in NK-mediated anti-tumor immunotherapy

Por Davis, Zachary B., Vallera, Daniel A., Miller, Jeffrey S., Felices, Martin
Publicado no Semin Immunol (2017)

Bispecific Targeting of EGFR and Urokinase Receptor (uPAR) Using Ligand-Targeted Toxins in Solid Tumors

Por Oh, Felix, Modiano, Jaime F., Bachanova, Veronika, Vallera, Daniel A.
Publicado no Biomolecules (2020)

Targeting EGFR and uPAR on human rhabdomyosarcoma, osteosarcoma, and ovarian adenocarcinoma with a bispecific ligand-directed toxin

Por Oh, Felix, Todhunter, Deborah, Taras, Elizabeth, Vallera, Daniel A, Borgatti, Antonella
Publicado no Clin Pharmacol (2018)

Bioengineering a unique deimmunized bispecific targeted toxin that simultaneously recognizes human CD22 and CD19 receptors in a mouse model of B cell metastases

Por Vallera, Daniel A., Oh, Seunguk, Chen, Hua, Shu, Yanqun, Frankel, Arthur E.
Publicado em 2010

Self-Assembling Antibodies by Chemical Induction

Por Li, Qing, Hapka, David, Chen, Hua, Vallera, Daniel A., Wagner, Carston R.
Publicado em 2008

Enhanced ADCC and NK Cell Activation of an Anticarcinoma Bispecific Antibody by Genetic Insertion of a Modified IL-15 Cross-linker

Por Schmohl, Joerg U, Felices, Martin, Taras, Elizabeth, Miller, Jeff S, Vallera, Daniel A
Publicado no Mol Ther (2016)

Development of a Deimmunized Bispecific Immunotoxin dDT2219 against B-Cell Malignancies

Por Schmohl, Joerg U., Todhunter, Deborah, Taras, Elizabeth, Bachanova, Veronika, Vallera, Daniel A.
Publicado no Toxins (Basel) (2018)

Generation of BiKEs and TriKEs to improve NK cell-mediated targeting of tumor cells

Por Felices, Martin, Lenvik, Todd R., Davis, Zachary B., Miller, Jeffrey S., Vallera, Daniel A.
Publicado no Methods Mol Biol (2016)

Genetic Alteration of a bispecific ligand directed toxin targeting human CD19 and CD22 receptors resulting in improved efficacy against systemic B cell malignancy

Por Vallera, Daniel A., Chen, Hua, Sicheneder, Andrew R., Panoskaltsis-Mortari, Angela, Taras, Elizabeth P.
Publicado em 2009

A new drug delivery method of bispecific ligand-directed toxins that reduces toxicity and promotes efficacy in a model of orthotopic pancreatic cancer

Por Oh, Seunguk, Stish, Brad J, Vickers, Selwyn M., Buchsbaum, Donald J., Vallera, Daniel A.
Publicado em 2010

Tetraspecific scFv construct provides NK cell mediated ADCC and self-sustaining stimuli via insertion of IL-15 as a cross-linker

Por Schmohl, Joerg U., Felices, Martin, Todhunter, Deborah, Taras, Elizabeth, Miller, Jeffrey S., Vallera, Daniel A.
Publicado no Oncotarget (2016)

A novel “reduced immunogenicity” bispecific targeted toxin simultaneously recognizing human EGF and IL-4 receptors in a mouse model of metastatic breast carcinoma

Por Oh, Seunguk, Stish, Brad J, Sachdev, Deepali, Chen, Hua, Dudek, Arkadiusz Z., Vallera, Daniel A.
Publicado em 2009

A novel bispecific ligand-directed toxin designed to simultaneously target EGFR on human glioblastoma cells and uPAR on tumor neovasculature

Por Tsai, Alexander K., Oh, Seunguk, Chen, Hua, Shu, Yanqun, Ohlfest, John R., Vallera, Daniel A.
Publicado em 2010

A deimmunized bispecific ligand directed toxin that shows an impressive anti-pancreatic cancer effect in a systemic nude mouse orthotopic model

Por Oh, Seunguk, Todhunter, Deborah A., Panoskaltsis-Mortari, Angela, Buchsbaum, Donald J., Toma, Shoko, Vallera, Daniel A.
Publicado em 2012

Chemically Self-assembled Antibody Nanorings (CSANs): Design and Characterization of an Anti-CD3 IgM Biomimetic

Por Li, Qing, So, Christopher R., Fegan, Adrian, Cody, Vivian, Sarikaya, Mehmet, Vallera, Daniel A., Wagner, Carston R.
Publicado em 2010

Hemangiosarcoma and its cancer stem cell sub-population are effectively killed by a toxin targeted through epidermal growth factor and urokinase receptors

Por Schappa, Jill T, Frantz, Aric M, Gorden, Brandi H, Dickerson, Erin B, Vallera, Daniel A, Modiano, Jaime F
Publicado em 2013