Enhanced ADCC and NK Cell Activation of an Anticarcinoma Bispecific Antibody by Genetic Insertion of a Modified IL-15 Cross-linker

Previously, we constructed a bispecific NK-cell-engager (BiKE) bearing single-chain variable fragments (scFv) against CD16 on NK cells and EpCAM on tumor cells. This BiKE facilitated antigen-specific antibody-dependent cell-mediated cytotoxicity (ADCC) but did not induce NK cell expansion. We incorp...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Schmohl, Joerg U, Felices, Martin, Taras, Elizabeth, Miller, Jeff S, Vallera, Daniel A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5088765/
https://ncbi.nlm.nih.gov/pubmed/27157665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2016.88
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