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Genetic Alteration of a bispecific ligand directed toxin targeting human CD19 and CD22 receptors resulting in improved efficacy against systemic B cell malignancy
A bispecific ligand-directed toxin (BLT) called DT2219ARL consisting of two sFv ligands recognizing CD19 and CD22 and catalytic DT390 was genetically enhanced for superior in vivo anti-leukemia activity. Genetic alterations included reverse orienting VH-VL domains and adding aggregation reducing/sta...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2738628/ https://ncbi.nlm.nih.gov/pubmed/19327829 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2009.02.006 |
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