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Mutagenic Deimmunization of Diphtheria Toxin for Use in Biologic Drug Development
Background: Targeted toxins require multiple treatments and therefore must be deimmunized. We report a method of protein deimmunization based on the point mutation of highly hydrophilic R, K, D, E, and Q amino acids on the molecular surface of truncated diphtheria-toxin (DT390). Methods: Based on th...
Sparad:
| I publikationen: | Toxins (Basel) |
|---|---|
| Huvudupphovsmän: | , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
MDPI
2015
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4626721/ https://ncbi.nlm.nih.gov/pubmed/26473923 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins7104067 |
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