Caspases: Therapeutic Targets in Neurologic Disease

Por Troy, Carol M., Jean, Ying Y.
Publicado no Neurotherapeutics (2014)

Cell Cycle Molecules Define A Pathway Required For Neuron Death In Development And Disease

Por Greene, Lloyd A., Liu, David X., Troy, Carol M., Biswas, Subhas C.
Publicado em 2006

Cystatin C protects neuronal cells from amyloid β-induced toxicity

Por Tizon, Belen, Ribe, Elena M., Mi, Weiqian, Troy, Carol M., Levy, Efrat
Publicado em 2010

Caspase-9 mediates synaptic plasticity and memory deficits of Danish dementia knock-in mice: caspase-9 inhibition provides therapeutic protection

Por Tamayev, Robert, Akpan, Nsikan, Arancio, Ottavio, Troy, Carol M, D’Adamio, Luciano
Publicado em 2012

Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus

Por Jean, Ying Y., Baleriola, Jimena, Fà, Mauro, Hengst, Ulrich, Troy, Carol M.
Publicado no J Vis Exp (2015)

Combined suppression of CASP2 and CASP6 protects retinal ganglion cells from apoptosis and promotes axon regeneration through CNTF-mediated JAK/STAT signalling

Por Vigneswara, Vasanthy, Akpan, Nsikan, Berry, Martin, Logan, Ann, Troy, Carol M., Ahmed, Zubair
Publicado em 2014

The Parkinson Disease Protein Leucine-Rich Repeat Kinase 2 Transduces Death Signals via Fas-Associated Protein with Death Domain and Caspase-8 in a Cellular Model of Neurodegenerat...

Por Ho, Cherry Cheng-Ying, Rideout, Hardy J., Ribe, Elena, Troy, Carol M., Dauer, William T.
Publicado em 2009

Caspase-2 is required for dendritic spine and behavioral alterations in J20 APP transgenic mice

Por Pozueta, Julio, Lefort, Roger, Ribe, Elena M., Troy, Carol M., Aran-cio, Ottavio, Shelanski, Michael
Publicado no Nat Commun (2013)

Selective Inhibition of Hypoxia-Inducible Factor (HIF) Prolyl-Hydroxylase 1 Mediates Neuroprotection against Normoxic Oxidative Death via HIF- and CREB-Independent Pathways

Por Siddiq, Ambreena, Aminova, Leila R., Troy, Carol M., Suh, Kyungsun, Messer, Zachary, Semenza, Gregg L., Ratan, Rajiv R.
Publicado em 2009

Neuronal caspase 2 activity and function requires RAIDD, but not PIDD

Por Ribe, Elena M., Jean, Ying Y., Goldstein, Rebecca L., Manzl, Claudia, Stefanis, Leonidas, Villunger, Andreas, Troy, Carol M.
Publicado em 2012

Axonally synthesized ATF4 transmits a neurodegenerative signal across brain regions

Por Baleriola, Jimena, Walker, Chandler A., Jean, Ying Y., Crary, John F., Troy, Carol M., Nagy, Peter L., Hengst, Ulrich
Publicado em 2014

Caspase-2 is essential for c-Jun transcriptional activation and Bim induction in neuron death

Por Jean, Ying Y., Ribe, Elena M., Pero, Maria Elena, Moskalenko, Marina, Iqbal, Zarah, Marks, Lianna J., Greene, Lloyd A., Troy, Carol M.
Publicado em 2013

Caspase-9 Mediates Photoreceptor Death After Blunt Ocular Trauma

Por Blanch, Richard J., Ahmed, Zubair, Thompson, Adam R., Akpan, Nsikan, Snead, David R. J., Berry, Martin, Troy, Carol M., Scott, Robert A. H., Logan, Ann
Publicado no Invest Ophthalmol Vis Sci (2014)

Endogenous Amyloid-β is Necessary for Hippocampal Synaptic Plasticity and Memory

Por Puzzo, Daniela, Privitera, Lucia, Fa', Mauro, Staniszewski, Agnieszka, Hashimoto, Gakuji, Aziz, Fahad, Sakurai, Mikako, Ribe, Elena M., Troy, Carol M., Mercken, Marc, Jung, Sonia S., Palmeri, Agostino, Arancio, Ottavio
Publicado em 2011

Intranasal Delivery of Caspase-9 Inhibitor Reduces Caspase-6-Dependent Axon/Neuron Loss and Improves Neurological Function after Stroke

Por Akpan, Nsikan, Serrano-Saiz, Esther, Zacharia, Brad E., Otten, Marc L., Ducruet, Andrew F., Snipas, Scott J., Liu, Wen, Velloza, Jennifer, Cohen, Greg, Sosunov, Sergeyi A., Frey, William H., Salvesen, Guy S., Connolly, E. Sander, Troy, Carol M.
Publicado em 2011

Mutations in CRADD Result in Reduced Caspase-2-Mediated Neuronal Apoptosis and Cause Megalencephaly with a Rare Lissencephaly Variant

Por Di Donato, Nataliya, Jean, Ying Y., Maga, A. Murat, Krewson, Briana D., Shupp, Alison B., Avrutsky, Maria I., Roy, Achira, Collins, Sarah, Olds, Carissa, Willert, Rebecca A., Czaja, Agnieszka M., Johnson, Rachel, Stover, Jessi A., Gottlieb, Steven, Bartholdi, Deborah, Rauch, Anita, Goldstein, Amy, Boyd-Kyle, Victoria, Aldinger, Kimberly A., Mirzaa, Ghayda M., Nissen, Anke, Brigatti, Karlla W., Puffenberger, Erik G., Millen, Kathleen J., Strauss, Kevin A., Dobyns, William B., Troy, Carol M., Jinks, Robert N.
Publicado no Am J Hum Genet (2016)