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Caspase-2 is required for dendritic spine and behavioral alterations in J20 APP transgenic mice
Caspases play critical roles in Alzheimer’s disease (AD) pathogenesis. Here we show that caspase-2 is required for the cognitive decline seen in hAPP transgenic mice (J20). The age-related changes in behavior and dendritic spine density observed in these mice are absent when they lack caspase-2, in...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4398315/ https://ncbi.nlm.nih.gov/pubmed/23748737 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2927 |
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