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Cross-Linking of Cell Surface Amyloid Precursor Protein Leads to Increased β-Amyloid Peptide Production in Hippocampal Neurons: Implications for Alzheimer's Disease
The accumulation of the β-amyloid peptide (Aβ) in Alzheimer's disease (AD) is thought to play a causative role in triggering synaptic dysfunction in neurons, leading to their eventual demise through apoptosis. Aβ is produced and secreted upon sequential cleavage of the amyloid precursor protein...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Society for Neuroscience
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3539764/ https://ncbi.nlm.nih.gov/pubmed/22855816 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6473-11.2012 |
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