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Linking folding with aggregation in Alzheimer's β-amyloid peptides

Growing evidence suggests that the β-amyloid (Aβ) peptides of Alzheimer's disease are generated in early endosomes and that small oligomers are the principal toxic species. We sought to understand whether and how the solution pH, which is more acidic in endosomes than the extracellular environm...

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Bibliographic Details
Main Authors: Khandogin, Jana, Brooks, Charles L.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2007
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2040412/
https://ncbi.nlm.nih.gov/pubmed/17942695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0703832104
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