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Linking folding with aggregation in Alzheimer's β-amyloid peptides
Growing evidence suggests that the β-amyloid (Aβ) peptides of Alzheimer's disease are generated in early endosomes and that small oligomers are the principal toxic species. We sought to understand whether and how the solution pH, which is more acidic in endosomes than the extracellular environm...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2040412/ https://ncbi.nlm.nih.gov/pubmed/17942695 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0703832104 |
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