Influence of Residue 22 on the Folding, Aggregation Profile, and Toxicity of the Alzheimer's Amyloid β Peptide

Several biophysical techniques have been used to determine differences in the aggregation profile (i.e., the secondary structure, aggregation propensity, dynamics, and morphology of amyloid structures) and the effects on cell viability of three variants of the amyloid β peptide involved in Alzheimer...

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Main Authors: Perálvarez-Marín, Alex, Mateos, Laura, Zhang, Ce, Singh, Shalini, Cedazo-Mínguez, Ángel, Visa, Neus, Morozova-Roche, Ludmilla, Gräslund, Astrid, Barth, Andreas
Format: Artigo
Jezik:Inglês
Izdano: The Biophysical Society 2009
Teme:
Protein
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711388/
https://ncbi.nlm.nih.gov/pubmed/19580765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.04.017
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