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Reversal of long-term dendritic spine alterations in Alzheimer disease models

Synapse loss is strongly correlated with cognitive impairment in Alzheimer's disease (AD). We have previously reported the loss of dendritic spines and the presence of dystrophic neurites in both the hippocampi of transgenic mice overexpressing amyloid precursor protein (APP) and in the human b...

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Detalhes bibliográficos
Main Authors: Smith, Donna L., Pozueta, Julio, Gong, Bing, Arancio, Ottavio, Shelanski, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2743726/
https://ncbi.nlm.nih.gov/pubmed/19805389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0908706106
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