Hypoxia and oxidative stress in breast cancer: Tumour hypoxia – therapeutic considerations

Autor Williams, Kaye J, Cowen, Rachel L, Stratford, Ian J
Vydáno 2001

Comparison of Doxycycline Delivery Methods for Tet-Inducible Gene Expression in a Subcutaneous Xenograft Model

Autor Cawthorne, Christopher, Swindell, Ric, Stratford, Ian J., Dive, Caroline, Welman, Arkadiusz
Vydáno 2007

Dissecting the role of multiple reductases in bioactivation and cytotoxicity of the antitumor agent RH1

Autor Yan, Chao, Kepa, Jadwiga K., Siegel, David, Stratford, Ian J., Ross, David
Vydáno 2008

Radiation enhances the therapeutic effect of Banoxantrone in hypoxic tumour cells with elevated levels of nitric oxide synthase

Autor MEHIBEL, MANAL, SINGH, SIMENDRA, COWEN, RACHEL L., WILLIAMS, KAYE J., STRATFORD, IAN J.
Vydáno v Oncol Rep (2016)

PCAF is a HIF-1α cofactor that regulates p53 transcriptional activity in hypoxia

Autor Xenaki, Georgia, Ontikatze, Teona, Rajendran, Ramkumar, Stratford, Ian J., Dive, Caroline, Krstic-Demonacos, Marija, Demonacos, Constantinos
Vydáno 2008

In silico screening reveals structurally diverse, nanomolar inhibitors of NQO2 that are functionally active in cells and can modulate NFκB signalling

Autor Nolan, Karen A., Dunstan, Mark S., Caraher, Mary C., Scott, Katherine A., Leys, David, Stratford, Ian J.
Vydáno 2011

Site and Strain-Specific Variation in Gut Microbiota Profiles and Metabolism in Experimental Mice

Autor Friswell, Melissa K., Gika, Helen, Stratford, Ian J., Theodoridis, Georgios, Telfer, Brian, Wilson, Ian D., McBain, Andrew J.
Vydáno 2010

The two common polymorphic forms of human NRH-quinone oxidoreductase 2 (NQO2) have different biochemical properties

Autor Megarity, Clare F., Gill, James R.E., Clare Caraher, M., Stratford, Ian J., Nolan, Karen A., Timson, David J.
Vydáno 2014

Akt inhibition improves long‐term tumour control following radiotherapy by altering the microenvironment

Autor Searle, Emma J, Telfer, Brian A, Mukherjee, Debayan, Forster, Duncan M, Davies, Barry R, Williams, Kaye J, Stratford, Ian J, Illidge, Tim M
Vydáno v EMBO Mol Med (2017)

Hypoxia-Mediated Down-Regulation of Bid and Bax in Tumors Occurs via Hypoxia-Inducible Factor 1-Dependent and -Independent Mechanisms and Contributes to Drug Resistance

Autor Erler, Janine T., Cawthorne, Christopher J., Williams, Kaye J., Koritzinsky, Marianne, Wouters, Bradley G., Wilson, Clare, Miller, Crispin, Demonacos, Costas, Stratford, Ian J., Dive, Caroline
Vydáno 2004

Glucocorticoid receptor over-expression promotes human small cell lung cancer apoptosis in vivo and thereby slows tumor growth

Autor Sommer, Paula, Cowen, Rachel L, Berry, Andrew, Cookson, Ann, Telfer, Brian A, Williams, Kaye J, Stratford, Ian J, Kay, Paul, White, Anne, Ray, David W
Vydáno 2010

Inhibition of poly(ADP-ribose) polymerase-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft

Autor Senra, Joana M., Telfer, Brian A., Cherry, Kim E., McCrudden, Cian M., Hirst, David G., O’Connor, Mark J., Wedge, Stephen R., Stratford, Ian J.
Vydáno 2011

Inhibition of Monocarboxylate transporter-1 (MCT1) by AZD3965 enhances radiosensitivity by reducing lactate transport

Autor Bola, Becky M., Chadwick, Amy L., Michopoulos, Filippos, Blount, Kathryn G., Telfer, Brian A., Williams, Kaye J., Smith, Paul D, Critchlow, Susan E., Stratford, Ian J.
Vydáno v Mol Cancer Ther (2014)

Hypoxia and hyperglycaemia determine why some endometrial tumours fail to respond to metformin

Autor Sivalingam, Vanitha N., Latif, Ayşe, Kitson, Sarah, McVey, Rhona, Finegan, Katherine G., Marshall, Kay, Lisanti, Michael P., Sotgia, Federica, Stratford, Ian J., Crosbie, Emma J.
Vydáno v Br J Cancer (2019)

Statin-induced metabolic reprogramming in head and neck cancer: a biomarker for targeting monocarboxylate transporters

Autor Mehibel, Manal, Ortiz-Martinez, Fernando, Voelxen, Nadine, Boyers, Amy, Chadwick, Amy, Telfer, Brian A., Mueller-Klieser, Wolfgang, West, Catharine M., Critchlow, Susan E., Williams, Kaye J., Stratford, Ian J.
Vydáno v Sci Rep (2018)

A novel systemically administered toll-like receptor 7 agonist potentiates the effect of ionizing radiation in murine solid tumor models

Autor Adlard, Amy L, Dovedi, Simon J, Telfer, Brian A, Koga-Yamakawa, Erina, Pollard, Charlotte, Honeychurch, Jamie, Illidge, Timothy M, Murata, Masashi, Robinson, David T, Jewsbury, Philip J, Wilkinson, Robert W, Stratford, Ian J
Vydáno v Int J Cancer (2014)

Utilizing the adjuvant properties of CD1d-dependent NK T cells in T cell–mediated immunotherapy

Autor Silk, Jonathan D., Hermans, Ian F., Gileadi, Uzi, Chong, Tsung Wen, Shepherd, Dawn, Salio, Mariolina, Mathew, Bini, Schmidt, Richard R., Lunt, Sarah Jane, Williams, Kaye J., Stratford, Ian J., Harris, Adrian L., Cerundolo, Vincenzo
Vydáno 2004

Monocarboxylate Transporter 1 (MCT1) is an independent prognostic biomarker in endometrial cancer

Autor Latif, Ayşe, Chadwick, Amy L., Kitson, Sarah J., Gregson, Hannah J., Sivalingam, Vanitha N., Bolton, James, McVey, Rhona J., Roberts, Stephen A., Marshall, Kay M., Williams, Kaye J., Stratford, Ian J., Crosbie, Emma J.
Vydáno v BMC Clin Pathol (2017)

Intravenous administration of the selective toll-like receptor 7 agonist DSR-29133 leads to anti-tumor efficacy in murine solid tumor models which can be potentiated by combination...

Autor Dovedi, Simon J., Adlard, Amy L., Ota, Yosuke, Murata, Masashi, Sugaru, Eiji, Koga-Yamakawa, Erina, Eguchi, Ken, Hirose, Yuko, Yamamoto, Setsuko, Umehara, Hiroki, Honeychurch, Jamie, Cheadle, Eleanor J., Hughes, Gareth, Jewsbury, Philip J., Wilkinson, Robert W., Stratford, Ian J., Illidge, Timothy M.
Vydáno v Oncotarget (2016)

Expression of NAD(P)H quinone dehydrogenase 1 (NQO1) is increased in the endometrium of women with endometrial cancer and women with polycystic ovary syndrome

Autor Atiomo, William, Shafiee, Mohamad Nasir, Chapman, Caroline, Metzler, Veronika M., Abouzeid, Jad, Latif, Ayşe, Chadwick, Amy, Kitson, Sarah, Sivalingam, Vanitha N., Stratford, Ian J., Rutland, Catrin S., Persson, Jenny L., Ødum, Niels, Fuentes‐Utrilla, Pablo, Jeyapalan, Jennie N., Heery, David M., Crosbie, Emma J., Mongan, Nigel P.
Vydáno v Clin Endocrinol (Oxf) (2017)