Controlling Extra- and Intramacrophagic Mycobacterium abscessus by Targeting Mycolic Acid Transport

Por Viljoen, Albertus, Herrmann, Jean-Louis, Onajole, Oluseye K., Stec, Jozef, Kozikowski, Alan P., Kremer, Laurent
Publicado no Front Cell Infect Microbiol (2017)

Biological Evaluation of Potent Triclosan-Derived Inhibitors of the Enoyl-Acyl Carrier Protein Reductase InhA in Drug-sensitive and Drug-resistant Strains of Mycobacterium tubercul...

Por Stec, Jozef, Vilchèze, Catherine, Lun, Shichun, Perryman, Alexander L., Wang, Xin, Freundlich, Joel S., Bishai, William, Jacobs, William R., Kozikowski, Alan P.
Publicado em 2014

Structure and Dynamics of the Liver Receptor Homolog 1–PGC1α Complex

Por Mays, Suzanne G., Okafor, C. Denise, Tuntland, Micheal L., Whitby, Richard J., Dharmarajan, Venkatasubramanian, Stec, Józef, Griffin, Patrick R., Ortlund, Eric A.
Publicado no Mol Pharmacol (2017)

Synthesis, Biological Evaluation and Structure-Activity Relationships of N-Benzoyl-2-hydroxybenzamides as Agents Active against P. falciparum (K1 strain), Trypanosomes, and Leishma...

Por Stec, Jozef, Huang, Qingqing, Pieroni, Marco, Kaiser, Marcel, Fomovska, Alina, Mui, Ernest, Witola, William H., Bettis, Samuel, McLeod, Rima, Brun, Reto, Kozikowski, Alan P.
Publicado em 2012

Crystal Structures of the Nuclear Receptor, Liver Receptor Homolog 1, Bound to Synthetic Agonists

Por Mays, Suzanne G., Okafor, C. Denise, Whitby, Richard J., Goswami, Devrishi, Stec, Józef, Flynn, Autumn R., Dugan, Michael C., Jui, Nathan T., Griffin, Patrick R., Ortlund, Eric A.
Publicado no J Biol Chem (2016)

Development of a triclosan scaffold which allows for adaptations on both the A- and B-ring for transport peptides

Por Muench, Stephen P., Stec, Jozef, Zhou, Ying, Afanador, Gustavo A., McPhillie, Martin J., Hickman, Mark, Lee, Patty J., Leed, Susan E., Auschwitz, Jennifer M., Prigge, Sean T., Rice, David W., McLeod, Rima
Publicado em 2013

Small Molecule Agonists of the Orphan Nuclear Receptors Steroidogenic Factor-1 (SF-1, NR5A1) and Liver Receptor Homologue-1 (LRH-1, NR5A2)

Por Whitby, Richard J., Stec, Jozef, Blind, Raymond D., Dixon, Sally, Leesnitzer, Lisa M., Orband-Miller, Lisa A., Williams, Shawn P., Willson, Timothy M., Xu, Robert, Zuercher, William J., Cai, Fang, Ingraham, Holly A.
Publicado em 2011

Modification of Triclosan Scaffold in Search of Improved Inhibitors for Enoyl-Acyl Carrier Protein (ACP) Reductase in Toxoplasma gondii

Por Stec, Jozef, Fomovska, Alina, Afanador, Gustavo A., Muench, Stephen P., Zhou, Ying, Lai, Bo-Shiun, Bissati, Kamal El, Hickman, Mark R., Lee, Patty J., Leed, Susan E., Auschwitz, Jennifer M., Sommervile, Caroline, Woods, Stuart, Roberts, Craig W., Rice, David, Prigge, Sean T., McLeod, Rima, Kozikowski, Alan P.
Publicado em 2013

Discrimination of Potent Inhibitors of Toxoplasma gondii Enoyl-Acyl Carrier Protein Reductase by Thermal Shift Assay

Por Afanador, Gustavo A., Muench, Stephen P., McPhillie, Martin, Fomovska, Alina, Schön, Arne, Zhou, Ying, Cheng, Gang, Stec, Jozef, Freundlich, Joel S., Shieh, Hong-Ming, Anderson, John W., Jacobus, David P., Fidock, David A., Kozikowski, Alan P., Fishwick, Colin W., Rice, David W., Freire, Ernesto, McLeod, Rima, Prigge, Sean T.
Publicado em 2013

Novel N-Benzoyl-2-Hydroxybenzamide Disrupts Unique Parasite Secretory Pathway

Por Fomovska, Alina, Huang, Qingqing, El Bissati, Kamal, Mui, Ernest J., Witola, William H., Cheng, Gang, Zhou, Ying, Sommerville, Caroline, Roberts, Craig W., Bettis, Sam, Prigge, Sean T., Afanador, Gustavo A., Hickman, Mark R., Lee, Patty J., Leed, Susan E., Auschwitz, Jennifer M., Pieroni, Marco, Stec, Jozef, Muench, Stephen P., Rice, David W., Kozikowski, Alan P., McLeod, Rima
Publicado em 2012