Small Molecule Agonists of the Orphan Nuclear Receptors Steroidogenic Factor-1 (SF-1, NR5A1) and Liver Receptor Homologue-1 (LRH-1, NR5A2)

[Image: see text] The crystal structure of LRH-1 ligand binding domain bound to our previously reported agonist 3-(E-oct-4-en-4-yl)-1-phenylamino-2-phenyl-cis-bicyclo[3.3.0]oct-2-ene 5 is described. Two new classes of agonists in which the bridgehead anilino group from our first series was replaced...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteurs: Whitby, Richard J., Stec, Jozef, Blind, Raymond D., Dixon, Sally, Leesnitzer, Lisa M., Orband-Miller, Lisa A., Williams, Shawn P., Willson, Timothy M., Xu, Robert, Zuercher, William J., Cai, Fang, Ingraham, Holly A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
Onderwerpen:
Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151520/
https://ncbi.nlm.nih.gov/pubmed/21391689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm1014296
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items