Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution

Chronic endoplasmic reticulum (ER) stress results in toxicity that contributes to multiple human disorders. We report a stress resolution pathway initiated by the nuclear receptor LRH-1 that is independent of known unfolded protein response (UPR) pathways. Like mice lacking primary UPR components, h...

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Hlavní autoři: Mamrosh, Jennifer L, Lee, Jae Man, Wagner, Martin, Stambrook, Peter J, Whitby, Richard J, Sifers, Richard N, Wu, San-Pin, Tsai, Ming-Jer, DeMayo, Francesco J, Moore, David D
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2014
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3987120/
https://ncbi.nlm.nih.gov/pubmed/24737860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.01694
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