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Human Endoplasmic Reticulum Mannosidase I Is Subject to Regulated Proteolysis

In the early secretory pathway, opportunistic cleavage of asparagine-linked oligosaccharides by endoplasmic reticulum (ER) mannosidase I targets misfolded glycoproteins for dislocation into the cytosol and destruction by 26 S proteasomes. The low basal concentration of the glycosidase is believed to...

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Detalhes bibliográficos
Main Authors: Wu, Ying, Termine, Daniel J., Swulius, Matthew T., Moremen, Kelley W., Sifers, Richard N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3969733/
https://ncbi.nlm.nih.gov/pubmed/17166854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M607156200
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