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Development of a triclosan scaffold which allows for adaptations on both the A- and B-ring for transport peptides

The enoyl acyl-carrier protein reductase (ENR) enzyme is harboured within the apicoplast of apicomplexan parasites providing a significant challenge for drug delivery, which may be overcome through the addition of transductive peptides, which facilitates crossing the apicoplast membranes. The bindin...

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Detalhes bibliográficos
Main Authors: Muench, Stephen P., Stec, Jozef, Zhou, Ying, Afanador, Gustavo A., McPhillie, Martin J., Hickman, Mark, Lee, Patty J., Leed, Susan E., Auschwitz, Jennifer M., Prigge, Sean T., Rice, David W., McLeod, Rima
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3683578/
https://ncbi.nlm.nih.gov/pubmed/23664871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.04.035
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