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Development of a triclosan scaffold which allows for adaptations on both the A- and B-ring for transport peptides
The enoyl acyl-carrier protein reductase (ENR) enzyme is harboured within the apicoplast of apicomplexan parasites providing a significant challenge for drug delivery, which may be overcome through the addition of transductive peptides, which facilitates crossing the apicoplast membranes. The bindin...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3683578/ https://ncbi.nlm.nih.gov/pubmed/23664871 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.04.035 |
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