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The benzimidazole based drugs show good activity against T. gondii but poor activity against its proposed enoyl reductase enzyme target
The enoyl acyl-carrier protein reductase (ENR) enzyme of the apicomplexan parasite family has been intensely studied for antiparasitic drug design for over a decade, with the most potent inhibitors targeting the NAD(+) bound form of the enzyme. However, the higher affinity for the NADH co-factor ove...
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| 主要な著者: | , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3966656/ https://ncbi.nlm.nih.gov/pubmed/24398298 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.12.066 |
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