The benzimidazole based drugs show good activity against T. gondii but poor activity against its proposed enoyl reductase enzyme target

The enoyl acyl-carrier protein reductase (ENR) enzyme of the apicomplexan parasite family has been intensely studied for antiparasitic drug design for over a decade, with the most potent inhibitors targeting the NAD(+) bound form of the enzyme. However, the higher affinity for the NADH co-factor ove...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Wilkinson, Craig, McPhillie, Martin J., Zhou, Ying, Woods, Stuart, Afanador, Gustavo A., Rawson, Shaun, Khaliq, Farzana, Prigge, Sean T., Roberts, Craig W., Rice, David W., McLeod, Rima, Fishwick, Colin W., Muench, Stephen P.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2013
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3966656/
https://ncbi.nlm.nih.gov/pubmed/24398298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.12.066
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