The benzimidazole based drugs show good activity against T. gondii but poor activity against its proposed enoyl reductase enzyme target

The enoyl acyl-carrier protein reductase (ENR) enzyme of the apicomplexan parasite family has been intensely studied for antiparasitic drug design for over a decade, with the most potent inhibitors targeting the NAD(+) bound form of the enzyme. However, the higher affinity for the NADH co-factor ove...

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Główni autorzy: Wilkinson, Craig, McPhillie, Martin J., Zhou, Ying, Woods, Stuart, Afanador, Gustavo A., Rawson, Shaun, Khaliq, Farzana, Prigge, Sean T., Roberts, Craig W., Rice, David W., McLeod, Rima, Fishwick, Colin W., Muench, Stephen P.
Format: Artigo
Język:Inglês
Wydane: 2013
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Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3966656/
https://ncbi.nlm.nih.gov/pubmed/24398298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.12.066
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