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Design, synthesis, and biological activity of diaryl ether inhibitors of Toxoplasma gondii enoyl reductase
Triclosan is a potent inhibitor of Toxoplasma gondii enoyl reductase (TgENR), which is an essential enzyme for parasite survival. In view of triclosan’s poor druggability, which limits its therapeutic use, a new set of B-ring modified analogs were designed to optimize its physico-chemical properties...
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| 主要な著者: | , , , , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3625046/ https://ncbi.nlm.nih.gov/pubmed/23453069 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.02.019 |
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