Design, synthesis, and biological activity of diaryl ether inhibitors of Toxoplasma gondii enoyl reductase

Triclosan is a potent inhibitor of Toxoplasma gondii enoyl reductase (TgENR), which is an essential enzyme for parasite survival. In view of triclosan’s poor druggability, which limits its therapeutic use, a new set of B-ring modified analogs were designed to optimize its physico-chemical properties...

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Detalhes bibliográficos
Main Authors: Cheng, Gang, Muench, Stephen P., Zhou, Ying, Afanador, Gustavo A., Mui, Ernest J., Fomovska, Alina, Lai, Bo Shiun, Prigge, Sean T., Woods, Stuart, Roberts, Craig W., Hickman, Mark R., Lee, Patty J., Leed, Susan E., Auschwitz, Jennifer M., Rice, David W., McLeod, Rima
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625046/
https://ncbi.nlm.nih.gov/pubmed/23453069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.02.019
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