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Spiroindolone That Inhibits PfATPase4 Is a Potent, Cidal Inhibitor of Toxoplasma gondii Tachyzoites In Vitro and In Vivo
Here, we show that spiroindolone, an effective treatment for plasmodia, is also active against Toxoplasma gondii tachyzoites. In vitro, spiroindolone NITD609 is cidal for tachyzoites (50% inhibitory concentration [IC(50)], 1μM) and not toxic to human cells at ≥10μM. Two daily oral doses of 100 mg/kg...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Microbiology
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3957861/ https://ncbi.nlm.nih.gov/pubmed/24366743 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02225-13 |
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