Triazine Inhibits Toxoplasma gondii Tachyzoites In Vitro and In Vivo

The triazine WR99210 [4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(2,4,5-trichlorophenoxypropyloxy)-1,3,5 triazine] inhibits Toxoplasma gondii in vitro at nanomolar levels (P < 0.05). The 50% inhibitory concentration (IC(50)) was approximately 50 nM. It is a potent inhibitor in vitro and is also effec...

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Bibliographische Detailangaben
Hauptverfasser: Mui, Ernest J., Jacobus, David, Milhous, Wilbur K., Schiehser, Guy, Hsu, Honghue, Roberts, Craig W., Kirisits, Michael J., McLeod, Rima
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2005
Schlagworte:
Experimental Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1196210/
https://ncbi.nlm.nih.gov/pubmed/16048961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.8.3463-3467.2005
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