Novel N-Benzoyl-2-Hydroxybenzamide Disrupts Unique Parasite Secretory Pathway

Toxoplasma gondii is a protozoan parasite that can damage the human brain and eyes. There are no curative medicines. Herein, we describe our discovery of N-benzoyl-2-hydroxybenzamides as a class of compounds effective in the low nanomolar range against T. gondii in vitro and in vivo. Our lead compou...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Fomovska, Alina, Huang, Qingqing, El Bissati, Kamal, Mui, Ernest J., Witola, William H., Cheng, Gang, Zhou, Ying, Sommerville, Caroline, Roberts, Craig W., Bettis, Sam, Prigge, Sean T., Afanador, Gustavo A., Hickman, Mark R., Lee, Patty J., Leed, Susan E., Auschwitz, Jennifer M., Pieroni, Marco, Stec, Jozef, Muench, Stephen P., Rice, David W., Kozikowski, Alan P., McLeod, Rima
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2012
Schlagworte:
Mechanisms of Action: Physiological Effects
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3346615/
https://ncbi.nlm.nih.gov/pubmed/22354304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.06450-11
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge