Novel N-Benzoyl-2-Hydroxybenzamide Disrupts Unique Parasite Secretory Pathway

Toxoplasma gondii is a protozoan parasite that can damage the human brain and eyes. There are no curative medicines. Herein, we describe our discovery of N-benzoyl-2-hydroxybenzamides as a class of compounds effective in the low nanomolar range against T. gondii in vitro and in vivo. Our lead compou...

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Autors principals: Fomovska, Alina, Huang, Qingqing, El Bissati, Kamal, Mui, Ernest J., Witola, William H., Cheng, Gang, Zhou, Ying, Sommerville, Caroline, Roberts, Craig W., Bettis, Sam, Prigge, Sean T., Afanador, Gustavo A., Hickman, Mark R., Lee, Patty J., Leed, Susan E., Auschwitz, Jennifer M., Pieroni, Marco, Stec, Jozef, Muench, Stephen P., Rice, David W., Kozikowski, Alan P., McLeod, Rima
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2012
Matèries:
Mechanisms of Action: Physiological Effects
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3346615/
https://ncbi.nlm.nih.gov/pubmed/22354304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.06450-11
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