Identification, Mutational Analysis, and Coactivator Requirements of Two Distinct Transcriptional Activation Domains of the Saccharomyces cerevisiae Hap4 Protein

Por Stebbins, John L., Triezenberg, Steven J.
Publicado em 2004

The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases

Por Landry, Joseph, Sutton, Ann, Tafrov, Stefan T., Heller, Ryan C., Stebbins, John, Pillus, Lorraine, Sternglanz, Rolf
Publicado em 2000

Inhibition of Siah2 ubiquitin ligase by vitamin K3 (menadione) attenuates hypoxia and MAPK signaling and blocks melanoma tumorigenesis

Por Shah, Meera, Stebbins, John L., Dewing, Antimone, Qi, Jianfei, Pellecchia, Maurizio, Ronai, Ze’ev A.
Publicado em 2009

STRUCTURE-BASED DISCOVERY OF A NEW CLASS OF Bcl-x(L) ANTAGONISTS

Por Rega, Michele F., Leone, Marilisa, Jung, Dawoon, Cotton, Naomi J.H., Stebbins, John L., Pellecchia, Maurizio
Publicado em 2007

Design, Synthesis and Bio-evaluation of an EphA2-based Targeted Delivery System

Por Barile, Elisa, Wang, Si, Das, Swadesh K., Noberini, Roberta, Dahl, Russell, Stebbins, John L., Pasquale, Elena B., Fisher, Paul B., Pellecchia, Maurizio
Publicado em 2014

Development of Paramagnetic Probes for Molecular Recognition Studies in Protein Kinases

Por Vazquez, Jesus, De, Surya K., Chen, Li-Hsing, Riel-Mehan, Megan, Emdadi, Aras, Cellitti, Jason, Stebbins, John L., Rega, Michele F., Pellecchia, Maurizio
Publicado em 2008

Design and characterization of a potent and selective dual ATP- and substrate-competitive sub-nanomolar bi-dentate c-Jun N-terminal Kinase (JNK) inhibitor

Por Stebbins, John L., De, Surya K., Pavlickova, Petra, Chen, Vida, Machleidt, Thomas, Chen, Li-Hsing, Kuntzen, Christian, Kitada, Shinichi, Karin, Michael, Pellecchia, Maurizio
Publicado em 2011

A novel targeted system to deliver chemotherapeutic drugs to EphA2-expressing cancer cells

Por Wang, Si, Placzek, William J., Stebbins, John L., Mitra, Sayantan, Noberini, Roberta, Koolpe, Mitchell, Zhang, Ziming, Dahl, Russell, Pasquale, Elena B., Pellecchia, Maurizio
Publicado em 2012

Design, Synthesis, and Structure-Activity Relationship Studies of Thiophene- 3-carboxamide Derivatives as Dual Inhibitors of the c-Jun N-Terminal Kinase

Por De, Surya K., Barile, Elisa, Chen, Vida, Stebbins, John L., Cellitti, Jason F., Machleidt, Thomas, Carlson, Coby B., Yang, Li, Dahl, Russell, Pellecchia, Maurizio
Publicado em 2011

Novel MT1-MMP small molecule inhibitors based on insights into hemopexin domain function in tumor growth()

Por Remacle, Albert G., Golubkov, Vladislav S., Shiryaev, Sergey A., Dahl, Russell, Stebbins, John L., Chernov, Andrei V., Cheltsov, Anton V., Pellecchia, Maurizio, Strongin, Alex Y.
Publicado em 2012

Structure Based Design of Covalent Siah Inhibitors

Por Stebbins, John L., Santelli, Eugenio, Feng, Yongmei, De, Surya K., Purves, Angela, Motamedchaboki, Khatereh, Wu, Bainan, Ronai, Ze’ev A., Liddington, Robert C., Pellecchia, Maurizio
Publicado em 2013

Identification of small molecules interfering with H1N1 influenza A viral replication

Por Bottini, Angel, De, Surya K., Baaten, Bas J. G., Wu, Bainan, Barile, Elisa, Soonthornvacharin, Stephen, Stebbins, John L., Bradley, Linda M., Chanda, Sumit K., Pellecchia, Maurizio
Publicado em 2012

Design and characterization of novel EphA2 agonists for targeted delivery of chemotherapy to cancer cells

Por Wu, Bainan, Wang, Si, De, Surya K., Barile, Elisa, Quinn, Bridget A., Zharkikh, Irina, Purves, Angela, Stebbins, John L., Oshima, Robert G., Fisher, Paul B., Pellecchia, Maurizio
Publicado no Chem Biol (2015)

Design, Synthesis, and Structure-Activity Relationship of Substrate Competitive, Selective, and in Vivo Active Triazole and Thiadiazole inhibitors of the c-Jun N-Terminal Kinase

Por De, Surya K., Stebbins, John L., Chen, Li-Hsing, Riel-Mehan, Megan, Machleidt, Thomas, Dahl, Russell, Yuan, Hongbin, Emdadi, Aras, Barile, Elisa, Chen, Vida, Murphy, Ria, Pellecchia, Maurizio
Publicado em 2009

Discovery of 2-(5-nitrothiazol-2-ylthio)benzo[d]thiazoles as novel c-Jun N-terminal kinase inhibitors

Por De, Surya K., Chen, Li-Hsing, Stebbins, John L., Machleidt, Thomas, Riel-Mehan, Megan, Dahl, Russell, Chen, Vida, Yuan, Hongbin, Barile, Elisa, Emdadi, Aras, Murphy, Ria, Pellecchia, Maurizio
Publicado em 2009

Fragment-Based Design of Small Molecule X-Linked Inhibitor of Apoptosis Protein Inhibitors

Por Huang, Jui-Wen, Zhang, Ziming, Wu, Bainan, Cellitti, Jason F., Zhang, Xiyun, Dahl, Russell, Shiau, Chung-Wai, Welsh, Kate, Emdadi, Aras, Stebbins, John L., Reed, John C., Pellecchia, Maurizio
Publicado em 2008

Apogossypol Derivatives as Pan-active Inhibitors of Anti-apoptotic B-cell lymphoma/leukemia-2 (Bcl-2) Family Proteins

Por Wei, Jun, Kitada, Shinichi, Rega, Michele F., Stebbins, John L., Zhai, Dayong, Cellitti, Jason, Yuan, Hongbin, Emdadi, Aras, Dahl, Russell, Zhang, Ziming, Yang, Li, Reed, John C., Pellecchia, Maurizio
Publicado em 2009

Synthesis and Biological Evaluation of Apogossypolone Derivatives as Pan-active Inhibitors of Anti-apoptotic B-Cell Lymphoma/Leukemia-2 (Bcl-2) Family Proteins

Por Wei, Jun, Kitada, Shinichi, Stebbins, John L., Placzek, William, Zhai, Dayong, Wu, Bainan, Rega, Michele F., Zhang, Ziming, Cellitti, Jason, Yang, Li, Dahl, Russell, Reed, John C., Pellecchia, Maurizio
Publicado em 2010

Effective inhibition of melanoma by BI-69A11 is mediated by dual targeting of the AKT and NF-κB pathways

Por Feng, Yongmei, Barile, Elisa, De, Surya K., Stebbins, John L., Cortez, Apple, Aza-Blanc, Pedro, Villanueva, Jessie, Heryln, Meenhard, Krajewski, Stan, Pellecchia, Maurizio, Ronai, Ze’ev A., Chiang, Gary G.
Publicado em 2011

Sabutoclax, a Mcl-1 Antagonist, Inhibits Tumorigenesis in Transgenic Mouse and Human Xenograft Models of Prostate Cancer

Por Jackson, Roger S, Placzek, William, Fernandez, Ana, Ziaee, Shabnam, Chu, Chia-Yi, Wei, Jun, Stebbins, John, Kitada, Shinichi, Fritz, Gloria, Reed, John C, Chung, Leland W, Pellecchia, Maurizio, Bhowmick, Neil A
Publicado em 2012